butabarbital will decrease the extent or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
Reserve concomitant prescribing of such prescription drugs in individuals for whom other treatment method solutions are inadequate. Restrict dosages and durations towards the bare minimum essential. Monitor carefully for indications of respiratory depression and sedation.
lenacapavir will improve the degree or effect of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
As diazepam rectal gel is only meant for adjunctive use, the prescriber must make sure the affected person is obtaining an best regimen of standard anti-epileptic drug cure which is, Nonetheless, continuing to practical experience these characteristic episodes
enzalutamide will minimize the extent or influence of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
fosphenytoin will reduce the level or impact of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on.
Alcoholic beverages together with diazepam may well induce a synergistic enhancement with the hypotensive Homes of benzodiazepines and alcohol.[94]
diazepam will enhance the level or impact of atogepant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
Propylene glycol toxicity documented in sufferers treated with diazepam injection at doses noticeably increased than encouraged when it absolutely was getting used to take care of alcohol withdrawal signs at doses >900 mg/day Propylene glycol toxicity is related to an anion hole metabolic acidosis, serum hyperosmolality, and enhanced lactate
Result of coadministration of the dual CYP3A4 and CYP2C19 inhibitor with fedratinib hasn't been studied.
Diazepam, as with other benzodiazepine prescription drugs, can result in tolerance, Actual physical dependence, compound use ailment, and benzodiazepine withdrawal syndrome. Withdrawal from diazepam or other benzodiazepines usually leads to withdrawal indications similar to Individuals witnessed in the course of barbiturate or Liquor withdrawal.
Diazepam may be quantified in blood or plasma to confirm a prognosis of poisoning in hospitalized people, supply proof within an impaired driving arrest, or to aid within a medicolegal Dying investigation. Blood or plasma diazepam concentrations usually are in a range of get more info 0.
Keep an eye on Closely (two)diazepam will boost the amount or result of lemborexant by influencing hepatic/intestinal enzyme CYP3A4 metabolism.
If atropine, scopolamine or other premedications wanted, they need to be administered in separate syringes